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Research Articles

Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho G, Fanning S, Stirtz G, Levy O, Young-Pearse T, Selkoe D, Dettmer U*: Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proc Natl Acad Sci U S A. 2019 Sep 23. pii: 201903216. doi: 10.1073/pnas.1903216116. [Epub ahead of print]. (* corresponding author)

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U*, Lindquist S, Selkoe D*. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. (* corresponding authors)

Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U*: Studying α-Synuclein Conformation by Intact-Cell Cross-Linking. Methods Mol Biol. 2019;1948:77-91. doi: 10.1007/978-1-4939-9124-2_8. (* corresponding author)

Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease. Neuron. 2018 Oct 10;100(1):75-90.e5. doi: 10.1016/j.neuron.2018.09.014.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL: Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007.

Dettmer U*, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D: Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. (* corresponding author)

Dettmer U, Newman AJ, von Saucken VE Bartels T, Selkoe D: KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicityProc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe D: Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a.

Newman AJ, Selkoe D, Dettmer U*: A New Method for Quantitative Immunoblotting of Endogenous α-Synuclein; PLoS One. 2013 Nov 20;8(11):e81314. doi: 10.1371/journal.pone.0081314 (* corresponding author) 

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D: In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cellsJ Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311.

Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C: The Transmembrane Protein 147 (TMEM147) is a Component of the Nicalin-NOMO Protein ComplexJ Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548.

Haffner C, Dettmer U, Weiler T, Haass C: The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. J Biol Chem. 2007 Apr 6;282(14):10632-8.

Reviews/Commentaries

Yeboah F, Kim TE, Bill A*, Dettmer U*: Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiol Dis. 2019 Jul 24;132:104543. doi: 10.1016/j.nbd.2019.104543. [Epub ahead of print] Review. (* corresponding authors) 

Dettmer U*: Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease. Front Neurosci. 2018 Sep 25;12:623. doi: 10.3389/fnins.2018.00623. eCollection 2018. Review. (* corresponding author) 

Dettmer U, Selkoe D, Bartels T: New insights into cellular α-synuclein homeostasis in health and disease. Curr Opin Neurobiol. 2016 Feb;36:15-22. doi: 10.1016/j.conb.2015.07.007

Dettmer U, Bartels T: ExPLAining early synucleinopathies. Brain. 2015 Jun;138(Pt 6):1449-51. doi: 10.1093/brain/awv099

Selkoe D, Dettmer U, Luth E, Kim N, Newman AJ, Bartels T: Defining the native state of α-synuclein. Neurodegener Diseases. 2013 Oct 30; 13(2-3):114-7. doi: 10.1159/000355516.

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